Press Releases

HKBU Partner State Key Laboratory of Environmental and Biological Analysis develops novel method for early diagnosis of environmental pollutant-induced diseases

2018.7.17

Hong Kong Baptist University (HKBU) established in 2013 the “Partner State Key Laboratory of Environmental and Biological Analysis (Hong Kong Baptist University)”, a partner laboratory to the State Key Laboratory of Environmental Chemistry and Eco-toxicology on the Mainland and the first partner state key laboratory collaboration between the Chinese Academy of Sciences and HKBU. Director of the Laboratory Professor Cai Zongwei met the media today (17 July) and shared the latest development of the Laboratory and showcased the state-of-the-art facilities. The research team developed an integrated method based on mass spectrometry imaging, which is a promising direction of current cutting-edge research, on the study of nephrotoxicity. The development can be potentially applied to the early diagnosis of environmental pollutant-induced kidney diseases.

Professor Cai Zongwei said, "Our research team developed an integrated method involving mass spectrometry (MS)-based lipidomics and matrix-assisted laser desorption/ionization-MS imaging (MALDI-MSI) to analyse the degree of nephrotoxicity in mice exposed to environmental pollutants. Our team was able to investigate the detailed molecular mechanism by studying the MS-image changes in terms of spatial distribution of lipids in mice exposed to environmental pollutants. It could be used in novel specificity evaluation and early diagnosis of environmental pollutant-induced kidney diseases."

Professor Cai said the support from the National Key Research and Development Programs enables the research team to develop novel technology platforms in MS-based imaging and other technologies. In future, the team will strive to collaborate with other research groups with the aim of understanding the detailed molecular mechanisms of diseases related to environmental pollutants. He said another objective of the Laboratory is to nurture scientific research talent for both Hong Kong and the Mainland.